Figure 3.

Phenotypic similarity of NOS2-deficient and glucocorticoid-immunosuppressed mice infected with Mtb. (a) Survival times for Mtb Erdman-infected (10⁶ CFU i.v.) mice given 2.5 mg of HC s.c. on days 5 and 10 p.i. NOS2^+/+ (n = 16); NOS2^−/− (n = 18). Nonimmunosuppressed control groups received vehicle (0.2 ml PBS) alone. NOS2^+/+ (n = 17); NOS2^−/− (n = 19). Both HC-treated groups and NOS2^−/− mice were significantly different from PBS-treated wild-type controls (P < 0.0002, log rank). Data represent two independent experiments. (b) Organ mycobacterial burdens (means ± SEM) of infected mice (n = 5–10 per time point). HC-treated groups were examined earlier (day 20) due to overt illness. ∗, P < 0.0002 versus the PBS-treated wild-type group, ANOVA.