Table 1.

Comparison of net in vivo doubling times for Mtb Erdman in genetically deficient hosts

	Genotype		n	Inoculum	Treatment	Doubling time, hr
						Lung	Liver	Spleen
(i)*	NOS2+/+	(B6 × 129 F2-3)	15	106	Vehicle (PBS)	45	130	72
	NOS2−/−	(B6 × 129 F2-3)	20	106	Vehicle (PBS)	31	92	44
	NOS2+/+	(B6 × 129 F2-3)	15	106	Hydrocortisone	27	104	63
	NOS2−/−	(B6 × 129 F2-3)	20	106	Hydrocortisone	27	85	46
(ii)†	IFN-γ+/+	(B6 × 129 Fn)	12	106	Untreated	51	319	162
	IFN-γ−/−	(B6 × 129 Fn)	12	106	Untreated	43	50	70
(iii)‡	β2M+/+	(B6 Fn backcross)	8	106	Untreated	63	125	138
	β2M−/−	(B6 Fn backcross)	8	106	Untreated	78	214	183
(iv)§	TNFR1+/+	(B6 F3 backcross)	6	105	Untreated	125	R	288
	TNFR1−/−	(B6 F3 backcross)	6	105	Untreated	38	181	55

Doubling times calculated from mycobacillary counts according to ref. 3 during days 1–15 p.i. with the exception of (iv) (days 10–14 p.i.). Genetic background given in parentheses, and n equals the total number of mice for both time points. All inocula administered i.v. R denotes resolving (net replication at day 15 p.i. below day 1 p.i.). *Present study,  

^†from ref. 5,  

^‡from ref. 2, and  

^§from ref. 6.