Table 1.
Automated and differential counts of PB and BM from transgenic and wild-type mice
| Mice | PB
|
BM
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Hb, g/dl | Plt, 109/liter | WBC, 109/liter | M/L | Pro+blasts, % | M/L | M/E | Poly, % | Mye+meta, % | Pro+blasts, % | |
| Wild type | 15.1 ± 0.9 | 1,278 ± 201 | 11.0 ± 4.0 | 0.23 ± 0.1 | 0 | 3.54 ± 2.6 | 1.92 ± 0.8 | 34.1 ± 11.1 | 9.9 ± 5.2 | 3.0 ± 1.0 |
| Preleukemia | 17.7 ± 2.1 | 990 ± 299 | 9.1 ± 3.0 | 0.82 ± 0.7 | 0 | 11.38 ± 1.7 | 7.15 ± 5.2 | 43.6 ± 6.2 | 24.9 ± 10.0 | 7.9 ± 0.9 |
| Leukemia | 10.0 ± 5.7 | 280 ± 100 | 148.4 ± 114.4 | 7.75 ± 5.7 | 6.8 ± 4.9 | 38.2 ± 14.5 | 47.8 ± 16.3 | 35.2 ± 23.4 | 12.0 ± 8.8 | 46.3 ± 15.0 |
Preleukemia, transgenic mice showing some abnormal signs in PB, BM, or spleen but not having reached leukemic criteria; Hb, hemoglobin; Plt, platelet; M/L, ratio of various differentiation stage granulocytes (M) to lymphocytes (L); M/E, ratio of various differentiation stage granulocytes (M) to nucleated erythrocytes (E); Poly, polymorphonuclear granulocytes; Mye+meta, myelocytes plus metamyelocytes; Pro+blasts, promyelocytes plus blasts. The number of mice used in this analysis is as follows: 4 leukemia, 4 preleukemia, 5 wild-type for BM, and 10 wild-type for PB.