Table 3.
Characteristics of individuals stratified by APOE genotypes
| Males | Pe | Females | Pe | |||
|---|---|---|---|---|---|---|
| Without e4 (n=236) | With e4 (n=85) | Without e4 (n=329) | With e4 (n=94) | |||
| Trait | LS-Mean (SE) | LS-Mean (SE) | LS-Mean (SE) | LS-Mean (SE) | ||
| Age (year) | 39.3 (0.9) | 36.5 (1.6) | 0.12 | 40.6 (1.3) | 39.5 (1.8) | 0.51 |
| BMIa | 32.3 (0.9) | 34.6 (1.2) | 0.009 | 33.8 (1.2) | 35.6 (1.4) | 0.12 |
| BFb (%) | 30.9 (1.1) | 33.3 (1.3) | 0.012 | 42.9 (1.2) | 44.1 (1.4) | 0.18 |
| FG (mg/dl) | 115.9 (4.1) | 122.8 (6.3) | 0.24 | 130.0 (7.2) | 126.9 (8.8) | 0.79 |
| FI (mIU/l) | 28.8 (4.2) | 33.4 (5.1) | 0.042 | 24.8 (1.4) | 26.3 (2.7) | 0.25 |
| Diabetes status | ||||||
| Diabetic (%) | 18.6 | 26.0 | 0.17 | 25.2 | 23.4 | 0.63 |
| IGTc (%) | 10.6 | 7.0 | 0.33 | 6.4 | 6.4 | 0.99 |
| Lipids | ||||||
| TC (mg/dl) | 180.0 (3.6) | 178.8 (4.9) | 0.74 | 176.0 (3.7) | 175.6 (4.8) | 0.92 |
| HDL (mg/dl) | 43.7 (1.7) | 39.5 (2.1) | 0.029 | 45.3 (1.6) | 41.6 (1.9) | 0.012 |
| HDL-AHA | ||||||
| <40 (%) | 51.7 | 61.2 | 0.13 | 41.6 | 53.4 | 0.004 |
| 41–59 (%) | 37.3 | 35.2 | 0.56 | 44.4 | 40.4 | 0.15 |
| >60 (%) | 10.6 | 3.5 | 0.11 | 13.4 | 6.4 | 0.024 |
| LDL (mg/dl) | 115.4 (3.0) | 118.6 (4.1) | 0.44 | 109.9 (2.2) | 113.2 (3.2) | 0.29 |
| TG (mg/dl) | 130.2 (7.3) | 141.8 (10.1) | 0.10 | 126.8 (5.0) | 121.4 (7.7) | 0.62 |
| APOA-1 (mg/dl) | 1.33 (0.03) | 1.21 (0.03) | <0.001 | 1.38 (0.04) | 1.29 (0.04) | 0.004 |
| Dietaryd | ||||||
| Total (Kcal) | 2,373 (85) | 2,112 (128) | 0.075 | 1,914 (50) | 1,816 (91) | 0.65 |
| Carb (%) | 50.2 (1.0) | 50.4 (1.5) | 0.88 | 52.2 (0.8) | 53.2 (1.3) | 0.45 |
| Prot (%) | 14.3 (0.4) | 15.0 (0.6) | 0.46 | 14.0 (0.3) | 13.8 (0.5) | 0.67 |
| Fat (%) | 34.3 (0.9) | 32.9 (1.3) | 0.28 | 34.4 (0.6) | 33.8 (1.0) | 0.57 |
Genotypes pooled into two groups: those without e4 and those with e4 allele. P values indicate significant differences between genotypes, within sex
aBMI = kg/m2
bBF = body fat
cIGT = impaired glucose tolerance
dDietary traits = percent of total daily Kcal intake
eSignificant P ≤ 0.05 in generalized linear mixed models (continuous outcomes) or generalized estimating equations (categorical outcomes), which controlled for the correlation among members in the same pedigrees
FG = fasting glucose, FI = fasting insulin