Table 9. Enrichment of ECOBIM and non-ECOBIM COBIM nodes for GO subnetworks in the DIP CORE network.

GO term	Subnetwork nodes	ECOBIM nodes	Non-ECOBIM COBIM nodes
GO:0016072 rRNA metabolic process	0.83	0.91	n/a
GO:0006352 transcription initiation	0.82	1.00	n/a
GO:0006383 transcription from RNA polymerase III pro	0.77	1.00	0.00
GO:0042254 ribosome biogenesis and assembly	0.72	0.87	n/a
GO:0008380 RNA splicing	0.71	0.79	0.50
GO:0006839 mitochondrial transport	0.64	0.80	n/a
GO:0006360 transcription from RNA polymerase I pro	0.64	0.80	0.00
GO:0016071 mRNA metabolic process	0.63	0.75	0.40
GO:0006260 DNA replication	0.61	0.93	n/a
GO:0031123 RNA 3′-end processing	0.59	0.93	0.29
GO:0006399 tRNA metabolic process	0.50	1.00	0.00
GO:0007059 chromosome segregation	0.49	0.76	n/a
GO:0006944 membrane fusion	0.48	0.75	0.22
GO:0006508 proteolysis	0.46	0.77	n/a
GO:0051169 nuclear transport	0.44	0.80	0.47
GO:0006997 nuclear organization and biogenesis	0.43	1.00	0.33
GO:0000278 mitotic cell cycle	0.43	0.81	0.19
GO:0015931 nucleobase, nucleoside, nucleotide and n	0.42	0.63	n/a
GO:0006913 nucleocytoplasmic transport	0.42	0.80	0.41
GO:0051236 establishment of RNA localization	0.42	0.63	n/a
GO:0006366 transcription from RNA polymerase II pro	0.40	0.75	0.29
GO:0007010 cytoskeleton organization and biogenesis	0.40	0.78	0.00
GO:0048308 organelle inheritance	0.39	0.86	n/a
GO:0006401 RNA catabolic process	0.38	0.83	0.41
GO:0006461 protein complex assembly	0.38	1.00	n/a
GO:0045184 establishment of protein localization	0.37	0.89	0.38
GO:0009100 glycoprotein metabolic process	0.37	0.63	n/a
GO:0006412 translation	0.36	0.85	0.00
GO:0007005 mitochondrion organization and biogenes	0.35	0.91	n/a
GO:0006512 ubiquitin cycle	0.34	0.82	n/a
GO:0051325 interphase	0.33	0.83	0.00
GO:0016192 vesicle-mediated transport	0.31	0.71	0.18
GO:0000074 regulation of progression through cell cycl	0.31	0.73	0.18
GO:0000279 M phase	0.30	0.80	0.17
GO:0006974 response to DNA damage stimulus	0.28	0.67	0.11
GO:0006323 DNA packaging	0.26	1.00	0.16
GO:0006417 regulation of translation	0.26	0.80	n/a
GO:0016481 negative regulation of transcription	0.25	1.00	0.13
GO:0007001 chromosome organization and biogenesi	0.22	0.79	0.16
GO:0016458 gene silencing	0.22	1.00	0.00
GO:0040029 regulation of gene expression, epigenet	0.21	1.00	0.00
GO:0007047 cell wall organization and biogenesis	0.17	0.75	n/a

For each GO subnetwork that contributed at least one ECOBIM, the fractions of essential proteins among the subnetwork nodes, subnetwork ECOBIM nodes, and subnetwork non-ECOBIM COBIM nodes are shown.