Table 2. Effect of adherence rates and patterns on the risk of virologic rebound.

	Controls (n = 67)	Cases (n = 5)	OR* [95% CI]	P value
Percentage adherence rate§, mean (SD)	88.5 (2.2)	53.1 (7.3)	0.56 [0.37–0.81]	<0.002
No. of days without dose$, mean (SD)	2.1 (0.4)	5.0 (1.4)	1.15 [0.94–1.40]	0.16
No. of TI&, mean (SD)	1.2 (0.3)	8.0 (2.7)	1.38 [1.13–1.77]	<0.002
Longest interval w/o dose, mean in days (SD)	1.5 (0.4)	16.2 (3.9)	1.34 [1.15–1.68]	<0.0001

^*OR [95% CI]: Odds Ratio [95% confidence Interval] computed by conditional exact logistic regression. OR>1 means an increased probability of viral rebound.

^§OR and 95% CI are provided for a 10% increase in adherence rate.

^$Days without dose defined as drug discontinuations for more than 24 hours and less than 48 hours.

^&TI: Treatment interruptions defined as drug discontinuations for more than 48 hours.