Figure 1.

(A) Dose-response curve of the effect of the nonimmunosuppressive CsA analog, SDZ 211–811, on the functional expression in Xenopus oocytes of nicotinic α7 homo-oligomeric receptors. Each data point is a mean of near maximal nicotine (250 μM)-induced current responses from 2–7 oocytes from a single representative experiment. The error bars represent standard errors of the means. Example current traces from oocytes incubated in different concentrations of SDZ 211–811 are shown below the graph. The horizontal bars depict the duration of agonist application (≈3 sec). The recordings were carried out at a holding potential of −60 mV. (B) Dose-response curve of the effect of SDZ 211–811 on the functional expression in Xenopus oocytes of homo-oligomeric 5HT₃R. Each data point is a mean of near maximal serotonin (10 μM)-induced current responses from 4–6 oocytes from a single representative experiment. Representative traces are shown below the graph. Duration of agonist application was ≈5 sec and the holding potential was −60 mV.