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. 1997 May 13;94(10):5432–5437. doi: 10.1073/pnas.94.10.5432

Figure 2.

Figure 2

Effect of overexpression of rat brain cytoplasmic CyP, CyPA, and a CyPA mutant [CyPA(W121F)] lacking high affinity CsA-binding activity on the ability of CsA to reduce functional α7 receptor expression. The open bars represent CsA-treated oocytes (7 μM) [n = 7 for α7/Luc; n = 10 for α7/CyPA; and n = 6 for α7/CyPA(W121F) injected oocytes]. The α7/Luc oocytes are those in which luciferase cDNA in pcDNAI/AMP vector was coinjected with the receptor subunit as DNA dose control. The α7/CyPA and α7/CyPA(W121F) oocytes are those in which CyPA and CyPA(W121F) cDNA in pcDNAI/AMP vector were coinjected, respectively, with the receptor subunit. The filled bars represent vehicle-treated oocytes [n = 7 for α7/Luc; n = 9 for α7/CyPA; and n = 7 for α7/CyPA(W121F) injected oocytes]. The ratio of cDNAs in each coinjection was 1:1.