Table 1.
Distribution of nucleotide polymorphisms in five nuclear gene loci of C. immitis
| Locus | |||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chitin synthase (369 bp) | Dioxygenase (529 bp) | Orotidine decarboxylase (396 bp) | Serine proteinase (647 bp) | Chitinase (443 bp) | |||||||||||||||||||||||||||||||||
| Site | 1 | 2 | 2 | 3 | 8 | 10 | 10 | 11 | 12 | 2 | 2 | 4 | 4 | 5 | 6 | 6 | 6 | 4 | 5 | 6 | 7 | 8 | 8 | 8 | 8 | 7 | 8 | 9 | 10 | 10 | 10 | 10 | 11 | ||||
| 9 | 1 | 8 | 3 | 7 | 0 | 2 | 7 | 7 | 9 | 9 | 7 | 7 | 0 | 0 | 2 | 4 | 7 | 1 | 3 | 4 | 1 | 8 | 8 | 9 | 3 | 1 | 1 | 2 | 4 | 6 | 7 | 1 | |||||
| 2 | 9 | 8 | 9 | 2 | 5 | 0 | 9 | 2 | 2 | 4 | 3 | 6 | 6 | 6 | 3 | 7 | 7 | 7 | 2 | 4 | 2 | 5 | 7 | 1 | 0 | 1 | 0 | 4 | 1 | 9 | 2 | 1 | |||||
| Nucleic acids | |||||||||||||||||||||||||||||||||||||
| Con | A | G | T | G | C | C | G | C | T | C | A | A | G | C | C | A | A | G | C | C | G | G | A | C | A | C | T | T | C | T | C | C | G | ||||
| Strain | |||||||||||||||||||||||||||||||||||||
| S | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | G | A | . | . | . | . | . | . | . | ||||
| AZ1 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | C | . | . | . | . | . | . | . | . | . | . | C | ||||
| AZ2 | . | . | . | A | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | A | . | . | . | . | . | . | . | ||||
| TX1 | . | . | . | . | . | . | . | . | . | . | . | G | . | T | T | . | G | . | . | . | . | . | G | . | . | . | . | . | . | . | . | . | . | ||||
| TX2 | . | . | . | . | . | . | . | . | . | . | . | . | A | . | . | . | . | . | . | . | . | . | G | . | . | . | C | . | A | C | . | . | C | ||||
| MX1 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | C | . | . | . | . | . | . | G | . | . | . | . | . | . | . | . | . | . | ||||
| MX2 | . | . | . | . | . | . | . | . | . | . | . | . | A | . | . | . | . | . | . | . | . | . | G | . | . | . | . | . | . | . | . | . | . | ||||
| AG1-5 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | G | . | . | . | . | . | . | . | . | . | . | ||||
| CA1 | G | A | C | A | T | T | A | T | C | . | G | G | . | T | T | . | G | C | G | T | T | . | . | T | . | . | . | C | . | . | . | . | C | ||||
| CA2 | G | . | C | A | T | T | A | T | C | . | G | G | . | T | T | . | G | C | G | T | T | . | . | T | . | . | . | C | . | . | T | . | C | ||||
| CA3 | G | A | C | A | . | . | . | . | . | G | G | G | . | T | T | . | G | C | G | T | T | . | . | T | . | . | . | C | . | . | . | . | C | ||||
| CA4 | G | . | C | A | T | T | A | T | C | . | . | G | . | T | T | . | G | C | G | T | T | . | . | T | . | . | . | C | . | . | . | T | C | ||||
| CA5 | G | . | C | A | . | . | . | . | . | . | . | G | . | T | T | . | G | C | G | T | T | . | . | T | . | . | . | C | . | . | T | . | C | ||||
| Amino acids | |||||||||||||||||||||||||||||||||||||
| Con | G | K | L | E | D | I | K | D | N | T | I | L | A | H | Y | L | L | A | T | R | A | R | N | N | I | S | * | T | N | I | N | N | T | ||||
| Sub | . | . | . | . | . | . | . | . | . | S | V | . | . | . | . | . | . | P | S | . | S | S | D | . | V | Y | * | . | K | T | . | . | . | ||||
Numbers indicate positions in the reference sequences; dots indicate nucleotides or amino acids identical to the consensus sequence. Con, consensus; Sub, substitution; S, Silveira, old laboratory strain (California, 1951); AZ1,2, Tucson, AZ; CA1, Kern County, CA; CA2,3, Santa Barbara, CA; CA4,5, San Diego; TX1,2 San Antonio, TX; MX1,2, Monterrey, Mexico; AG1-5, Argentina. All isolates are clinical, except CA4,5 collected from soil, and AG1-5 from a variety of sources; isolates were obtained between 1969 and 1994. ∗, intron.