Figure 1.

Application of the neuron-specific System A transporter inhibitor MeAIB does not change mIPSC amplitude. A, B, This is illustrated by the representative traces comparing mIPSC recorded in control (Cont) conditions to mIPSC recorded after application of MeAIB (5 mm; A) and averaged mIPSCs under each condition from the same cell (147 and 228 events in control and in the presence of MeAIB, respectively; B). C, Cumulative distribution of the same mIPSC events averaged in B show no effect of 5 mm MeAIB in these minimal activity conditions. The bar graph in C plots mean median mIPSC amplitudes (amp.) for eight cells under control (open bar) and MeAIB-exposed (filled bar) conditions, demonstrating no effect of MeAIB on mIPSC amplitudes.