Figure 1.

Amino acid sequence comparisons of conserved motifs in some members of the newly recognized family of putative metalloproteases. A black box was assigned if 50% of the family members contained the identical residue at that position. A gray box was assigned if 50% of the family members had a similar residue at that position. Similar residues were I, L, V, and M; F, Y, and W; D and E; N and Q; S and T; A and G; and R and K. Amino acid positions are indicated. Gene name and species of origin are shown (Left). An alignment containing the entire 46-member family can be found on our website (http://mcb.harvard.edu/losick).