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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: Curr Opin Genet Dev. 2008 Feb 21;18(1):97–106. doi: 10.1016/j.gde.2007.12.001

Figure 4.

Figure 4

Quenched ABPs for the non-invasive imaging of tumors in vivo. (A) Covalent labeling of a cysteine protease target by a quenched ABP (GB137). Activity-based labeling of the target enzyme results in the loss of the quenching group and subsequent generation of a fluorescently-labeled enzyme. (B) Optical imaging of MDA-MB-231 breast cancer xenograft tumors in nude mice using a quenched cysteine cathepsin-specific ABP. The quenched probe was injected intravenously and fluorescent images of the mice were taken at various time points after injection. Images taken from reference 49.