Table 1.
Enzyme classes characterized using ABPs.
ABP | ABP structure | Proteome | Enzyme activity | References |
---|---|---|---|---|
FP-rhodamine | ![]() |
Human breast melanoma cell lines Human ER(+) and ER(−) breast tissue samples HT-hi/diss and HT-low/diss human fibrosarcoma cell lines MDA-MB-231 breast cancer cells before and after passage in mice |
Serine hydrolases | 18, 19, 20, 29 |
FP-biotin | ![]() |
Human ER(+) and ER(−) breast cancer tissue samples HT-hi/diss and HT-low/diss human fibrosarcoma cell lines |
Serine hydrolases | 19, 20 |
HxBP-Rh | ![]() |
Human melanoma cell lines Human breast cancer cell lines |
Metalloproteases | 17, 22 |
SAHA-BPyne | ![]() |
Human melanoma and breast cancer cell lines | Class I/II HDACs | 24 |
HAUb-VME | ![]() |
Cervical carcinoma biopsies tissue samples and cell lines Human tumor cell lines |
USPs | 25, 27 |
DCG-04 | ![]() |
PyMT/ctsb+/+, PyMT/ctsb−/−, and PyMT/ctsb+/− murine tumor cells RIP1-TAG2 murine normal and tumor cells | Cysteine cathepsins | 28, 42, 43 |
Phenyl-SE | ![]() |
MDA-MB-231 breast cancer cells before and after passage in mice Human breast cancer cell lines |
Multiple enzymes, including thiolases, sugar kinases, and glutathione S-transferases | 29, 30, 31, 32 |
GB137 | ![]() |
Human and mouse tumor cell lines MDA-MB-231 xenografted breast cancer cell lines from mice |
Cysteine cathepsins | 49 |