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. 2008 Jul 3;105(28):9793–9798. doi: 10.1073/pnas.0802917105

Fig. 4.

Fig. 4.

Transgenic Sirt1 mice are protected from HFD-induced hepatic glucose intolerance. (A) Glucose tolerance test (GTT) after 7 weeks of diet exposure by using an i.p. dose of 2 g of glucose per kg of body weight. (B) Pyruvate tolerance test (PTT) after 16 weeks of diet exposure by using 2 g of pyruvate per kg of body weight. (C) Insulin tolerance test (ITT) after 13 weeks of diet exposure by using 0.75 IU/kg insulin. Curves of glucose levels (Left) and values of the area under the curve (Right). n = 7–8 per group; means ± SEM; *, P < 0.05; **, P < 0.01; ***, P < 0.001.