Fig. 2.

The HCV network. A genomic network of HCV coordinated substitutions is shown, where a vertex is an amino acid site and a link between two vertices is a significant physicochemical correlation between two sites. The position of each vertex depends on its k-shell value and on the k-shell value of its neighbors. A color code allows for the identification of k-shell values, and the vertex's size is proportional to its degree. The k-shell decomposition and visualization was performed with LaNet-vi (31).