Fig. 3.

HCV network and natural selection. (A) Sites that compose the HCV network and their k-shell value, which is shown as a moving average (window size = 9; step = 1). (B) Average values of k-shell for each protein (squares), calculated by using 404 sites in the network, and the average of the dS/dN ratio (circles) calculated over all of the sites of the protein. The correlation between the average k-shell and dS/dN values in HCV proteins is 0.5930 (P = 0.00001). (C) Scatter plot of HCV proteins. The x axis is the percentage of the sites of each protein that are located in the nucleus (k-shell, 36) and y axis the average dS/dN.