Fig. 4.

Hypothetical molecular interactions between NS3, NS4A, and NS5A. The links between sites are shown as green lines (interprotein) or orange lines (intraprotein). Sites located in the nucleus of the HCV network are shown in red. NS3, 3D structure of the NS3 protease (sites 1029 to 1205). The first 28 N-terminal aa involved in the molecular interaction with its NS4A cofactor are shown in yellow and red. NS5A, 3D structure of NS5A (sites 2008 to 2170). The sites involved in the molecular interaction with NS4A (2135 to2139) are shown in yellow and red. NS4A, All 54 sites of NS4A are shown as a contiguous chain divided in four domains: the membrane anchor (green), the NS3 cofactor (yellow), the kink (blue), and the acidic domain (cyan).