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. 2007 Mar;8(1):21–28. doi: 10.2174/138920207780076910

Table 2.

Stage-Related Melanosome Proteins (Partial List)

Stages UniProtKB Gene Name Protein Name Notes
P36955 PEDF Pigment epithelium-derived factor precursor
P51148 RAB5C Ras-related protein Rab-5C (RAB5L) (L1880) Validated
P05556 ITGB1 Integrin beta-1
Stage I
Q9UMX9 Matp Membrane-associated transporter protein (SLC45A2) Homolog
O14880 MGST3 Microsomal glutathione S-transferase 3
Proposed
Q14254 FLOT2 Flotillin-2 (Epidermal surface antigen)
Q9UMX9 Matp Membrane-associated transporter protein (SLC45A2)
Homolog
Q04656 ATP7A Copper-transporting ATPase 1
Stage II Q9P0L0 VAPA Vesicle-associated membrane protein-associated protein A
P53992 SEC24C Protein transport protein Sec24C Proposed
O95782 AP2A Adapter-related protein complex 2 alpha- 1 subunit
O95670 ATP6G2 Vacuolar ATP synthase subunit G 2
Validated
Q71RS6 SLC24A Sodium/potassium/calcium exchanger 5 precursor
P57729 Rab-38 Ras-related protein Rab-38
P51159 RAB27A Ras-related protein Rab-27A (Rab-27)
Homolog
Q9Y4I1 Myo5a Myosin-5A (Myosin Va)
Stage IV Q99698 LYST Lysosomal trafficking regulator
Q16643 DBN1 Drebrin
P59998 ARPC4 Actin-related protein 2/3 complex subunit 4
P18206 VCL Vinculin (Metavinculin) Proposed
P63000 RAC1 Ras-related C3 botulinum toxin substrate 1 (p21-Rac1)
P51148 RAB5C Ras-related protein Rab-5C (RAB5L)

All proteins listed are identified in the melanosome proteomes. Validated –shown to be localized in melanosomes by immunostaining; Homolog – homologous to known mouse coat color genes; Proposed – proposed as protein of functional interest for validation.