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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Cell Metab. 2008 Jun;7(6):520–532. doi: 10.1016/j.cmet.2008.04.011

Figure 2. Fasting hypoglycemia, enhanced insulin sensitivity and reduced glycogen stores in the liver of ISR-defective Alb::GC transgenic mice.

Figure 2

A. Body weight (mean ± SEM, n=20) of non-transgenic (WT), heterozygous (GC/+) and homozygous Alb::GC (GC/GC) transgenic male mice as function of age.

B. Blood glucose after fasting of adult male mice of indicated genotype (mean ± SEM, n=4, *p<0.05, #p<0.01).

C. PAS stain (glycogen) of representative liver sections of fed and fasted mice of the indicated genotype.

D. Glycogen content of liver of fed and fasted (18 hr) mice of the indicated genotype (mean ± SEM, WT n=3, Alb::GC n=5, *p<0.05)

E. Blood glucose levels as a function of time after pyruvate loading in mice of the indicated genotype (mean ± SEM, n=5, p<0.001 two-way ANOVA).

F. Blood glucose as a function of time after intra-peritoneal injection of glucose in mice of the indicated genotype (mean ± SEM, n=3, p<0.001 versus WT by two-way ANOVA)

G. Blood glucose as a function of time (expressed as a percent of level at t=0) after intra-peritoneal injection of insulin in mice of the indicated genotype (mean ± SEM, n=4, p=0.005 versus WT by two-way ANOVA)