Table 2.

ECoG data for bolus dosing and steady-state seizure model with the correlation of 3-MPA concentration in the brain

Dose	Latency to seizure onset (s)	Brain [3-MPA] at seizure onset (μg/mL)	Number of seizures detectedc	Average seizure durationd (s)	Rmax
50 mg/kga	680.7 ± 123.5	6.11 ± 3.95	9 ± 2	1.72 ± 4.00	61.7 ± 38.1
100 mg/kga	510.2 ± 305.2	9.75 ± 3.00	603 ± 85	1.03 ± 2.11	123.8 ± 69.5
60 mg/kg bolus + 50 mg/(kg min−1) infusionb	363.2 ± 148.8	4.80 ± 2.03	592 ± 187	0.87 ± 1.78	71.8 ± 22.2

^an = 4.

^bn = 6.

^cp < 0.01.

^dRepresents the average of the average seizure duration for each experiment.