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. Author manuscript; available in PMC: 2008 Jul 18.

Published in final edited form as: Epilepsy Res. 2007 Mar 26;74(2-3):116–125. doi: 10.1016/j.eplepsyres.2007.02.003

Table 3.

Elimination pharmacokinetic parameters for constant infusion model

Dosing scheme	Sample	K_e (min⁻¹)
Constant infusion	Blood	0.034 ± 0.019
	Brain	0.030 ± 0.011
Constant infusion	Blood/brain	1.34 ± 0.48

A: average data from the blood (n = 9 rats) and brain (n = 16 rats); B: blood/brain ratios for elimination parameters.