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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Nucl Med Biol. 2008 May;35(4):447–458. doi: 10.1016/j.nucmedbio.2008.02.009

Figure 2.

Figure 2

The effects of pretreatment with selective monoamine transporter inhibitors on A: regional brain distribution and B: region-to-cerebellum ratios. While under isoflurane anesthesia, rats (n = 3) were injected with either sterile water, 2 mg/kg GBR12909 (selective DAT inhibitor), 10 mg/kg nisoxetine (selective NET inhibitor), or 2 mg/kg IDAM (selective SERT inhibitor) through the femoral vein 5 min before [18F]1 (90 µCi) injection. Two hours after tracer injection the tracer uptake in various brain regions were determined. Standard deviations are depicted by the error bars. A: IDAM considerably inhibits uptake into the striatum, hippocampus, cortex, and hypothalamus. B: Pretreatment with IDAM greatly decreased the region-to-cerebellum ratio. Negligible inhibition is seen with GBR12909, and minor inhibition is seen with nisoxetine pretreatment.