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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Nucl Med Biol. 2008 May;35(4):447–458. doi: 10.1016/j.nucmedbio.2008.02.009

Table 2.

Biodistribution of [18F]1 in male Sprague-Dawley rats (n = 3). While under isoflurane anesthesia, 40–100 µCi of [18F]1 was delivered by iv injection through the femoral vein.

Organ distribution in terms of % dose per organ
Region 2 min 30 min 60 min 120 min 180 min 240 min
Skin 7.72 ± 2.16 8.91 ± 1.39 9.75 ± 1.77 6.60 ± 0.67 3.86 ± 0.25 2.95 ± 0.24
Blood 6.95 ± 0.28 4.12 ± 0.41 3.30 ± 0.30 2.28 ± 0.54 1.21 ± 0.14 1.15 ± 0.08
Heart 0.90 ± 0.34 0.15 ± 0.03 0.10 ± 0.02 0.07 ± 0.01 0.04 ± 0.00 0.03 ± 0.01
Lung 10.1 ± 1.17 2.42 ± 0.31 1.45 ± 0.45 0.82 ± 0.15 0.47 ± 0.07 0.32 ± 0.00
Liver 6.27 ± 0.97 3.86 ± 0.20 3.43 ± 0.36 2.66 ± 0.70 2.37 ± 0.18 2.14 ± 0.32
Pancreas 0.78 ± 0.15 0.26 ± 0.00 0.17 ± 0.01 0.12 ± 0.03 0.05 ± 0.01 0.03 ± 0.01
Spleen 0.87 ± 0.09 0.61 ± 0.08 0.41 ± 0.08 0.19 ± 0.05 0.15 ± 0.02 0.09 ± 0.00
Kidney 6.00 ± 0.88 3.93 ± 0.58 3.59 ± 0.94 2.23 ± 0.80 2.34 ± 0.59 1.64 ± 0.81
Muscle 6.37 ± 0.26 9.94 ± 1.03 6.94 ± 1.36 4.48 ± 0.10 1.84 ± 0.16 1.42 ± 0.19
Bone 10.7 ± 1.47 8.79 ± 1.02 9.30 ± 1.00 8.84 ± 2.18 7.55 ± 0.33 8.83 ± 0.85
Brain 1.61 ± 0.02 1.23 ± 0.18 0.97 ± 0.18 0.59 ± 0.10 0.30 ± 0.01 0.24 ± 0.03
Regional brain distribution in terms of % dose per gram
Region 2 min 30 min 60 min 120 min 180 min 240 min
Hypothalamus 1.15 ± 0.11 1.22 ± 0.16 1.08 ± 0.21 0.75 ± 0.18 0.41 ± 0.02 0.34 ± 0.06
Striatum 0.92 ± 0.04 0.90 ± 0.17 0.74 ± 0.15 0.46 ± 0.10 0.16 ± 0.02 0.13 ± 0.00
Cortex 1.05 ± 0.07 1.00 ± 0.18 0.98 ± 0.18 0.44 ± 0.08 0.22 ± 0.09 0.12 ± 0.01
Hippocampus 0.89 ± 0.06 0.79 ± 0.11 0.65 ± 0.12 0.38 ± 0.04 0.20 ± 0.00 0.14 ± 0.02
Cerebellum 1.02 ± 0.11 0.35 ± 0.05 0.23 ± 0.07 0.10 ± 0.02 0.04 ± 0.00 0.03 ± 0.01
Region-to-cerebellum ratio calculated from % dose per gram values
Region 2 min 30 min 60 min 120 min 180 min 240 min
Hypothalamus 1.14 ± 0.15 3.50 ± 0.38 4.69 ± 0.74 7.67 ± 1.39 9.66 ± 0.21 10.1 ± 3.44
Striatum 0.90 ± 0.12 2.58 ± 0.30 3.19 ± 0.49 4.67 ± 0.29 3.88 ± 0.21 3.79 ± 0.64
Cortex 1.03 ± 0.12 2.87 ± 0.41 4.26 ± 0.96 4.53 ± 0.54 5.14 ± 1.87 3.64 ± 0.91
Hippocampus 0.88 ± 0.07 2.26 ± 0.25 2.82 ± 0.42 3.87 ± 0.50 4.65 ± 0.20 4.07 ± 0.88
Cerebellum 1.00 ± 0.00 1.00 ± 0.00 1.00 ± 0.00 1.00 ± 0.00 1.00 ± 0.00 1.00 ± 0.00