Table 2.
Mean (±SEM) ethanol intake (ml and g/kg), water intake (ml), ethanol preference (E:T), and food consumption (g) measured 24 hr following aCSF or NPY infusions into the CeA of P rats. Rats in the ABST group received infusions directly prior to re-exposure to ethanol availability following a 2-week period of ethanol abstinence. Rats in the CONT group had uninterrupted access to ethanol and were infused in parallel with rats in the ABST group. For ethanol intake, ANOVA indicated significant effects of group and the interaction of group with NPY dose.
ABST groups | ||||||
---|---|---|---|---|---|---|
NPY dose (μg) | n | Ethanol intake (ml) | Ethanol Intake (g/kg) | Water intake (ml) | Ethanol Preference | Food intake (g) |
0.0 (aCSF) | 5 | 20.06 ± 0.82 * | 8.03 ± 0.41 * | 14.92 ± 2.55 | 0.58 ± 0.05 | 12.36 ± 0.61 |
0.25 | 5 | 18.22 ± 2.31 | 7.79 ± 1.06 | 14.13 ± 1.14 | 0.56 ± 0.05 | 12.42 ± 0.61 |
0.5 | 7 | 13.91 ± 2.55 | 5.67 ± 1.01 | 19.26 ± 2.65 | 0.42 ± 0.07 | 14.71 ± 1.13 |
1.0 | 6 | 14.63 ± 1.60 # | 6.23 ± 0.77 | 16.68 ± 3.19 | 0.48 ± 0.07 | 14.28 ± 1.29 |
CONT groups | ||||||
NPY dose (μg) | n | Ethanol intake (ml) | Ethanol Intake (g/kg) | Water intake (ml) | Ethanol Preference | Food intake (g) |
| ||||||
0.0 (aCSF) | 5 | 11.78 ± 2.37 | 4.69 ± 0.89 | 20.64 ± 1.58 | 0.36 ± 0.06 | 14.22 ± 1.21 |
1.0 | 7 | 13.48 ± 1.14 | 5.62 ± 0.59 | 21.37 ± 2.07 | 0.40 ± 0.05 | 15.28 ± 0.89 |
p<0.05 significant difference between ABST and CONT groups that were infused with aCSF.
p<0.05 significant difference from aCSF group with identical drinking history.