Figure 8. Ependymal Cells Give Rise to Oligodendrocytes after Injury.

(A) Ependymal cell-derived progeny are most abundant within the core of the scar tissue forming at the injury (arrow). Ependyma-derived cells are also found, more sparsely, over a larger area in the intact tissue bordering the lesion (arrowheads), where they are associated with myelin basic protein (MBP)-immunoreactive myelin ensheathing neurofilament (NF)-immunoreactive axons.

(B–D) Ependymal cell-derived progeny harboring an oligodendrocytic morphology are found both in the grey (B) and white matter (C), and some recombined processes wrap around myelinated axon (D).

Scale bars indicate 100 μm in (A), 25 μm in (B) and (C), and 10 μm in (D).