Skip to main content
. Author manuscript; available in PMC: 2009 Jun 6.
Published in final edited form as: Mol Cell. 2008 Jun 6;30(5):599–609. doi: 10.1016/j.molcel.2008.03.020

Figure 6.

Figure 6

Models of eukaryotic stop codon recognition and translation termination. A) The location of key determinants of eRF1 function on the three-dimensional structure of human eRF1. Only the relevant portion of domain 1 is shown. Residues identified by genetic screens in this study or by Stansfield and co-workers (Bertram et al., 2000) are indicated in yellow (residues identified in this study are in black type, while those identified by Stansfield and co-workers are in purple type). White circles indicate cavities 1, 2, and 3. The residue designations and numbering corresponds to human eRF1 (+3 relative to Sc eRF1). B) Model for eukaryotic translation termination at UAA/UAG vs. UGA stop codons.