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Heart rate response to dobutamine. Ganglionic transmission was blocked with hexamethonium (average HR after hexamethonium: WT 538±18 bpm, p75-/- 514±19 bpm), and then the beta adrenergic agonist dobutamine (20 μg/kg) was infused. Dobutamine stimulated a larger heart rate increase in p75-/- mice (hatched bar) than wild type mice (solid bar). Data are mean±sem, n=4 WT, n=6 P75-/-, **p< 0.01.
