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Heart rate response to tyramine. Ganglionic transmission was blocked with hexamethonium, bringing heart rates to a similar level in both genotypes (WT 499±19, P75-/- 504±9). Tyramine (200 μg/kg) was infused to maximally stimulate release of NE from sympathetic nerve terminals, triggering increased heart rate in wild type (solid bars) and P75-/- (hatched bars) mice. Data are mean±sem, n=5 WT, n=6 P75-/-, ** p <0.005
