Table 3.

Adjusted odds ratio estimates ^a for cytokines within subsets of the study population defined by the interval between sample collection and pregnancy outcome, from conditional logistic regression models of miscarriage risk.

	Interval ≥ 10 days		Interval > 14 days		Interval > 21 days		Interval > 28 days		Interval > 35 days
	(439 cases, 373 controls)		(350 cases, 373 controls)		(259 cases, 373 controls)		(197 cases, 371 controls)		(135 cases, 371 controls)
	AOR	[95% CI]	AOR	[95% CI]	AOR	[95% CI]	AOR	[95% CI]	AOR	[95% CI]
IL-1β ^b	0.76	[0.59, 0.97]	0.72	[0.57, 0.92]	0.65	[0.46, 0.91]	0.58	[0.38, 0.90]	0.51	[0.28, 0.90]
IFN-γ ^b	1.09	[0.91, 1.31]	1.03	[0.85, 1.24]	0.94	[0.76, 1.16]	0.97	[0.77, 1.22]	0.98	[0.74, 1.28]
TNF-α ^b	0.94	[0.78, 1.13]	0.93	[0.77, 1.14]	0.96	[0.78, 1.18]	0.95	[0.75, 1.21]	0.90	[0.67, 1.22]
IL-1RA ^b	1.06	[0.91, 1.25]	1.06	[0.90, 1.25]	1.05	[0.87, 1.27]	1.02	[0.81, 1.29]	0.98	[0.73, 1.31]
IL-4 ^b	1.05	[0.89, 1.25]	1.08	[0.90, 1.29]	1.13	[0.93, 1.38]	1.07	[0.89, 1.29]	1.05	[0.86, 1.29]
IL-6 ^b	1.20	[0.97, 1.48]	1.22	[0.96, 1.55]	1.34	[1.02, 1.75]	1.45	[1.04, 2.00]	1.62	[1.08, 2.42]
G-CSF ^b	0.78	[0.65, 0.95]	0.84	[0.68, 1.02]	0.85	[0.67, 1.06]	0.91	[0.71, 1.17]	0.96	[0.72, 1.28]
TPO ^b	1.17	[1.00, 1.36]	1.19	[1.01, 1.40]	1.19	[1.00, 1.41]	1.19	[0.98, 1.43]	1.19	[0.96, 1.48]

Abbreviations: IL, interleukin; RA, receptor antagonist; TPO, thrombopoietin; G-CSF, granulocyte colony stimulating factor; IFN, interferon; TNF, tumor necrosis factor

Adjusted model included terms for all cytokines, maternal age, and gestational age at sample collection

Biomarkers were standardized by dividing assay-determined concentration by the standard deviation among controls