Table 1.
Analysis of murine mAbs 16a 1 and 16a6
MAb | Isotype | Binding to M. tuberculosis CDC 1551 (Heat-killed) | Binding to M. tuberculosis CDC 1551 (irradiated) | Binding to M. tuberculosis strains Erdman & TB1-TB9 | Peptide sequences of MPT51 identified following immunoprecipiation with mAb | VH | JH | VK | JK |
---|---|---|---|---|---|---|---|---|---|
16a1 | IgG1 | + | + | + | APYENLMVPSPSMGR
GISVVAPAPAGGAYSMYTNWEQDGSK GLAPGGHAAVGAAQGGYGAMALAAFHPDR WHDPWVHASLLAQNNTR VWVWSPTNPGASDPAAMIGQAAEAMGNSR MFYNQYRS |
7183 | 4 | 4
(subgroup 50) |
2 |
|
|
||||||||
16a6 | IgG1 | + | + | + | 7183 | 4 | 4
(subgroup 50) |
2 |