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Msh6−/− embryos are more resistant to alkylation damage and have reduced mutation frequencies. (A, B) Survival of wild-type (black) and msh6−/− (white) embryos at increasing doses of ENU (A) and MNU (B). (C, D) Mutation frequency measured by the albino loss-of-heterozygosity assay in wild-type (black) and msh6−/− (white) embryos induced by increasing doses of ENU (C) and MNU (D). Asterisks indicate significant differences. ND, not done.
