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MMR-dependent ENU-induced chromosomal instability arises during replication. (A) Induction of random DSBs during all phases of the cell cycle by IR does not result in surivival differences in between msh6−/− and wild-type embryos. (B) ENU sensitivity of wild-type and ku70 mutant. (C) IR sensitivity of wild type, tp53 mutant (control) and homozygous ku70 mutant. Asterisks indicate significant differences.
