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. 2008 Jun 6;36(12):4088–4098. doi: 10.1093/nar/gkn347

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Ku80 suppresses Rad51-mediated GC. Repair efficiency by GC assessed by the substrate pGC. Cells were pretreated for 16 h with siRNA and then transfected with the I-SceI expression plasmid. Shown is the mean fraction (± SE) of green fluorescent cells derived from three independent clones after 48 h. Cells not subjected to siRNA yielded essentially the same results as the scambled control (sc) (data not shown). Asterisk: actual value is 0.02%. Inset: Western blot for Rad51 expression in CHO K1 cells 48 h after transfection of siRNA. Anti-Rad51 siRNA (Rad51) reduced protein expression by 80% compared to scrambled control (sc).