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A hypothesis of competitive binding between Sox2 and Gata4/Nkx2.5. In undifferentiated ES cells, Sox2 binds to a regulatory sequence (bracket region) to repress a target gene, while Gata4 and Nkx2.5 are not expressed. Later upon differentiation, Gata4 and Nkx2.5, both highly expressed, out-compete Sox2 to bind to the same region, thus terminating the repression of the downstream gene.
