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Alternate promoter/operator arrangements tested to explore whether promoter overlap with O2 influences optimal loop lengths. (A) Arrangement tested by Muller et al. (52) with 57.5 bp operator spacing shown. (B) Original promoter/operator spacing in our studies (14) with 63.5 bp operator spacing shown. (C) Design tested to simulate arrangement in (A), with 55.5 bp spacing shown. Arrowheads in (B) and (C) indicate locations of inserted sequences that alter operator spacing.
