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. 2008 Aug 6;3(8):e2848. doi: 10.1371/journal.pone.0002848

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Dong et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A, Intracerebroventricular infusion of vehicle did not prevent the stimulation to Schaffer preceding commissural pathway (Δt<40 ms) from inducing LTP in both pathways in pentobarbital-anesthetized rats (n = 5; Schaffer: 125.7±3.2%; commissural: 123.9±6.2%; P<0.001 vs. baseline of Schaffer or commissural). B, Infusion of the NMDAR antagonist AP-5 prevented the stimulation to Schaffer preceding to commissural pathway within a 40-ms window from inducing LTP in both pathways (n = 6; Schaffer: 103.6±2.2%, P = 0.349 vs. baseline; commissural: 103.0±4.1%, P = 0.463 vs. baseline). C, Similarly, infusion of vehicle did not affect the stimulation to Schaffer preceding to commissural pathway within a 40-ms window to induce LTP in preceding and LTD in following pathway in urethane-anesthetized rats (n = 6; Schaffer, 116.8±3.2%; commissural, 81.4±2.3%, P<0.001 vs. baseline of pSchaffer or fcommissural). D, Infusion of the NMDAR antagonist AP-5 prevented the stimulation to Schaffer preceding to commissural pathway within a 40-ms window from inducing LTP and LTD (n = 4; Schaffer: 103.8±2.9%, P = 0.163 vs. baseline; commissural: 102.6±2.4%, P = 0.493 vs. baseline).