Figure 1. Schematic representation of the k-mutant Boltzmann ensemble sampled by RNAmutants.

The input RNA sequence is represented at the center while the k-neighbourhoods (Here k  =  1, 2) are represented by concentric rings. Each individual RNA sequence is associated with a set of secondary structures that can be mapped onto it (the boxed structures). These comprise the set of structure that have to be enumerated to compute the Boltzmann partition function).