FIGURE 10.

AR schematic diagrams. A, full-length human AR amino acid residues 1–919 contain the NH₂-terminal domain (NTD) with activation function-1 (AF1) and Ser-515, DNA binding domain (DBD) with Ser-578, and ligand binding domain (LBD) with activation domain-2 (AF2). B, ARNH₂-terminal and DNA binding domain residues 514–627 showing the two zinc modules with highlighted AR phosphorylation sites Ser-515 and Ser-578. C, structure of the AR DNA binding domain dimer (green) bound to androgen response element DNA (orange and blue) (52) with space-filled Ser-578 indicated with red arrows.