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. 2008 Jul;179(3):1197–1210. doi: 10.1534/genetics.108.089003

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Copyright © 2008 by the Genetics Society of America

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Figure 7.— — Genetic interaction of dot1 with BER and NER mutants. (A) Deletion of DOT1 suppresses the MMS sensitivity of BER and NER mutants. Fivefold serial dilutions of exponentially growing cells were spotted onto YPDA and 0.01 or 0.015% MMS plates. Strains are BR1919α (wild type), YP163 (dot1), YP978 (rad1), YP981 (rad1 dot1), YP979 (rad14), YP987 (rad14 dot1), YP980 (apn1), and YP992 (apn1 dot1). (B) Suppression of the rad52 MMS sensitivity by dot1 does not depend on NER or BER function. Fivefold dilutions of exponentially growing cells were spotted onto YPDA and 0.001% MMS plates. Strains are BR1919α (wild type), YP370 (rad52), YP371 (rad52 dot1), YP983 (rad1 rad52), YP985 (rad1 rad52 dot1), YP989 (rad14 rad52), YP990 (rad14 rad52 dot1), YP994 (apn1 rad52), and YP995 (apn1 rad52 dot1).