Figure 1.

Renal allograft rejection by skin-presensitized C57BL/6 recipients. A: C57BL/6 mice were either presensitized by DBA/2 skin graft rejection (▴, n = 24) or left nonsensitized (▪, n = 12) and then received DBA/2 renal allografts. B: Presensitized recipients were either left untreated (▴, n = 4) or were depleted of CD8 T cells (•, n = 4) at the time of renal allograft transplantation. Renal allograft rejection was considered at the time animals displayed signs of ill health and creatinine levels greater than 70 μmol/L.