Table 4.
Stem Cell IHC Profile in the Major Molecular Subtypes of IBC and Non-IBC
| IBC
|
Non-IBC
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Triple negative (n = 8) | Her-2/neu+ (n = 11) | ER+ (n = 6) | Total (n = 25) | Triple negative (n = 5) | Her-2/neu+ (n = 6) | ER+ (n = 14) | Total (n = 25) | |
| CD133+ | 7 (88) | 10 (91) | 5 (83) | 22 (88) | 2 (40) | 0 (0) | 0 (0) | 2 (08) |
| Notch+ | 6 (75) | 9 (82) | 4 (67) | 19 (76) | 2 (40) | 0 (0) | 0 (0) | 2 (08) |
Absolute numbers of cases and (% positivity) are listed. Differences for both CD133 and notch in IBC versus non-IBC were highly significant (P < 0.001); differences among subclasses of IBC were not significant (P > 0.1). Strong agreement between CD133 and notch was present in the IBC cases [weighted κ (95% confidence interval) = 0.86 (0.81, 0.91)].