Table 1B.

Pharmacology of Dopamine Receptors in Apis mellifera: Binding in Cell Cultures

	Specificity in vertebrates	AmDOP1 in HEK 293: [3H]LSD binding (Ki [nM])	AmDOP1 in Sf9: cAMP production (EC50 or IC50 [nM])	AmDOP2 in Sf9: amp production (EC50 or IC50 [nM])
Biogenic amines
DA		56	360	2,200
Norepinephrine		3,100	n.d.	58,000
5-HT		3,600	n.d.	−
TA		9,900	n.d.	−
OA		110,000	n.d.	n.d.
Dopamine receptor agonists
6,7-ADTN	DA receptor agonist	93	650	5,100
R(+)−SKF 38393	D1 agonist	4,200	n.d.	−
Dopamine receptor antagonists
R(+)−Lisuride	D2 agonist, D1 antagonist	4.3	+/−	+/−
Chlorpromazine	D2 antagonist	15	n.d.	+
cis(Z)-Flupentixol	DA receptor antagonist	17	200	3.8
Spiperone	selective D2 antagonist	64	2,200	8,500
R(+)− SCH 23390	selective D1 antagonist	250	8,100	17,000
S(+)−Butaclamol	DA receptor antagonist	77	540	81
Haloperidol	D2, D3, and D4 antagonist	390	n.d.	+

Values are from [14] for AmDOP1 in HEK 293 and from [104] for AmDOP1 in Sf9 and AmDOP2 in Sf9. Abbreviations: + = effective; +/−= intermediate; − = little or no effect; n.d. = not determined.