Table 1A.

Pharmacology of Dopamine Receptors in Apis mellifera: Binding to Brain Membrane Homogenate

	Specificity in vertebrates	Brain membrane homogenate: DA-sensitive [3H]LSD binding site (Ki [nM])	Brain membrane homogenate: [3H]SCH 23390 binding site (Ki [nM])	Brain membrane homogenate: [3H]spiperone binding site (Ki [nM])
Biogenic amines
DA		22	30,800	300
Norepinephrine		+/−	n.d.	n.d.
5-HT		7,000	548,000	18,300
TA		+/−	α1,000,000	45
OA		+/−	892,000	18
Dopamine receptor agonists
6,7-ADTN	DA receptor agonist	78	n.d	n.d.
R(+)-SKF 38393	D1 agonist	−	3,200	n.d.
Dopamine receptor antagonists
R(+)−Lisuride	D2 agonist, D1 antagonist	4.7	n.d.	n.d.
Chlorpromazine	D2 antagonist	48	208	n.d.
cis(Z)-Flupentixol	DA receptor antagonist	150	218	n.d.
Spiperone	selective D2 antagonist	+/−	25,400	0.17
R(+)− SCH 23390	selective D1 antagonist	+/−	9.5	456
S(+)−Butaclamol	DA receptor antagonist	89	13,800	55.5
Haloperidol	D2, D3, and D4 antagonist	+/−	n.d.	n.d.

Values are from [15] for the dopamine-sensitive [³H]LSD binding site, from [75] for the [³H]SCH 23390 and [³H]spiperone binding sites. Abbreviations: +/− = intermediate; −= little or no effect; n.d. = not determined.