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. 1965;33(6):783–794.

Studies on the pathogenesis of fixed rabies virus in rats*

G M Baer, T R Shanthaveerappa, G H Bourne
PMCID: PMC2475917  PMID: 5295402

Abstract

Investigations were made on the spread of fixed rabies virus after its inoculation into the rear foot-pads of rats. The presence of rabies virus in the central nervous system was first detected in the lumbar segment of the spinal cord. Removal of the sciatic nerve or of its fasciculus, either before or soon after challenge, drastically lowered mortality, thus giving evidence of a rapid neural spread of the infection. Neither the perineural structures nor the axons appeared to be involved. Although the presence of virus in the sciatic nerves was first demonstrated by the development of neutralizing antibodies in the serum of rats ”immunized” by multiple injections of nerve material from rats killed 48 hours after challenge, resection of nerves had to be carried out long before that time to be effective in preventing viral progression.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DEAN D. J., BAER G. M., THOMPSON W. R. Studies on the local treatment of rabies-infected wounds. Bull World Health Organ. 1963;28(4):477–486. [PMC free article] [PubMed] [Google Scholar]
  2. DEAN D. J., EVANS W. M., MCCLURE R. C. PATHOGENESIS OF RABIES. Bull World Health Organ. 1963;29:803–811. [PMC free article] [PubMed] [Google Scholar]
  3. DROZ B., LEBLOND C. P. AXONAL MIGRATION OF PROTEINS IN THE CENTRAL NERVOUS SYSTEM AND PERIPHERAL NERVES AS SHOWN BY RADIOAUTOGRAPHY. J Comp Neurol. 1963 Dec;121:325–346. doi: 10.1002/cne.901210304. [DOI] [PubMed] [Google Scholar]
  4. FRYE F. L., ENRIGHT J. B. OBSERVATIONS ON ERYTHROCYTIC INCLUSION BODIES FROM MICE INFECTED WITH RABIES VIRUS. Proc Soc Exp Biol Med. 1964 Mar;115:689–691. doi: 10.3181/00379727-115-29007. [DOI] [PubMed] [Google Scholar]
  5. GOLDWASSER R. A., KISSLING R. E. Fluorescent antibody staining of street and fixed rabies virus antigens. Proc Soc Exp Biol Med. 1958 Jun;98(2):219–223. doi: 10.3181/00379727-98-23996. [DOI] [PubMed] [Google Scholar]
  6. GOLDWASSER R. A., KISSLING R. E. Fluorescent antibody staining of street and fixed rabies virus antigens. Proc Soc Exp Biol Med. 1958 Jun;98(2):219–223. doi: 10.3181/00379727-98-23996. [DOI] [PubMed] [Google Scholar]
  7. HUYGELEN C. Further observations on the pathogenesis of rabies in guinea-pigs after experimental infection with the Flury strain. Antonie Van Leeuwenhoek. 1960;26:66–72. doi: 10.1007/BF02538994. [DOI] [PubMed] [Google Scholar]
  8. HUYGELEN C., MORTELMANS J. Quantitative determination of the dissemination of Flury rabies virus in the central nervous system of the guinea-pig after intramuscular inoculation in the hind leg. Antonie Van Leeuwenhoek. 1959;25:265–271. doi: 10.1007/BF02542851. [DOI] [PubMed] [Google Scholar]
  9. JOHNSON R. T. THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS. I. VIRUS PATHWAYS TO THE NERVOUS SYSTEM OF SUCKLING MICE DEMONSTRATED BY FLUORESCENT ANTIBODY STAINING. J Exp Med. 1964 Feb 1;119:343–356. doi: 10.1084/jem.119.2.343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. KOPROWSKI H., VAN DER SCHEER J., BLACK J. Use of hyperimmune anti-rabies serum concentrates in experimental rabies. Am J Med. 1950 Apr;8(4):412–420. doi: 10.1016/0002-9343(50)90224-5. [DOI] [PubMed] [Google Scholar]
  11. MCQUEEN J. L., LEWIS A. L., SCHNEIDER N. J. Rabies diagnosis by fluorescent antibody. I. Its evaluation in a public health laboratory. Am J Public Health Nations Health. 1960 Nov;50:1743–1752. doi: 10.2105/ajph.50.11.1743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. SHANTHAVEERAPPA T. R., BOURNE G. H. THE PERINEURAL EPITHELIUM OF SYMPATHETIC NERVES AND GANGLIA AND ITS RELATION TO THE PIA ARACHNOID OF THE CENTRAL NERVOUS SYSTEM AND PERINEURAL EPITHELIUM OF THE PERIPHERAL NERVOUS SYSTEM. Z Zellforsch Mikrosk Anat. 1964;61:742–753. doi: 10.1007/BF00342622. [DOI] [PubMed] [Google Scholar]
  13. SHANTHAVEERAPPA T. R., BOURNE G. H. THE PERINEURAL EPITHELIUM: NATURE AND SIGNIFICANCE. Nature. 1963 Aug 10;199:577–579. doi: 10.1038/199577a0. [DOI] [PubMed] [Google Scholar]
  14. SHANTHAVEERAPPA T. R., BOURNE G. H. The 'perineural epithelium', a metabolically active, continuous, protoplasmic cell barrier surrounding peripheral nerve fasciculi. J Anat. 1962 Oct;96:527–537. [PMC free article] [PubMed] [Google Scholar]
  15. Semple D. ON THE NATURE OF RABIES AND ANTIRABIC TREATMENT. Br Med J. 1919 Sep 13;2(3063):333–336. doi: 10.1136/bmj.2.3063.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. WIKTOR T. J., KOPROWSKI H. [Local action of various drugs on rabies infection in mice]. Bull World Health Organ. 1963;28(4):487–494. [PMC free article] [PubMed] [Google Scholar]
  17. WONG D. H., FREUND J. Fixed rabies virus in blood following intracerebral inoculation in mice and rabbits. Proc Soc Exp Biol Med. 1951 Apr;76(4):717–720. doi: 10.3181/00379727-76-18605. [DOI] [PubMed] [Google Scholar]

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