Figure 2.

Survival curves for mice of different genotypes at Skts12, Skts2, and Skts10. (a) The Kaplan–Meier survival curves for four groups with combinations of multiple resistance or susceptibility alleles: three resistance alleles (RRR), two resistance and one susceptibility (RRS), one resistance and two susceptibility (RSS), and three susceptibility alleles (SSS). Kaplan–Meier curves for survival time associated with homozygosity or heterozygosity at single markers of D6Mit 15 (b), at D7Mit12 (c), and at D17Mit7 (d) are also plotted by using the stata program. χ² and P values estimated by Cox regression analysis are indicated in each graph. The dotted line curve shows the survival curve for the total of 83 mice. We also confirmed that the P values from the Cox model analysis were comparable to those obtained from nonparametric numerical tests (log-rank and Wilcoxon) and from the Kaplan–Meier analysis (data not shown).