Table 1.
Empty and peptide-loaded cell-surface class II MHC molecules on antigen-presenting cells
| Cell type/Source | Haplotype | KL-304* | 10-2.16* | Y3P* | 11-5.2* | Control IG*† |
|---|---|---|---|---|---|---|
| B cells | ||||||
| Splenic | s | 2 (4) | 87 (21) | 86 (20) | — | 2 (4) |
| Splenic | k | 2 (4) | 98 (20) | — | 84 (21) | 3 (5) |
| Peritoneal | s | 2 (5) | 83 (22) | 82 (20) | — | 2 (1) |
| L.S.102.9‡ | s/d | 1 (6) | 90 (58) | 96 (45) | — | 2 (1) |
| Macrophages | ||||||
| Splenic | s | 8 (5) | 94 (24) | 91 (22) | — | 2 (2) |
| Splenic | k | 6 (4) | 92 (25) | — | 93 (26) | 3 (3) |
| Peritoneal | s | 5 (2) | 27 (28) | 24 (27) | — | 2 (2) |
| Peritoneal | k | 3 (2) | 35 (23) | — | 30 (25) | 3 (2) |
| Dendritic cells | ||||||
| Splenic | s | 93 (57) | 95 (330) | 94 (340) | — | 3 (4) |
| Splenic | k | 98 (89) | 97 (540) | — | 98 (771) | 3 (8) |
| Bone marrow | s | 90 (44) | 90 (58) | 90 (55) | — | 2 (3) |
| Bone marrow | k | 90 (36) | 59 (48) | — | 67 (45) | 2 (2) |
| Splenic | u | 89 (99) | 91 (279) | 93 (393) | — | 3 (8) |
| Splenic | f | 83 (45) | 83 (57) | 87 (84) | — | 2 (1) |
| Splenic | MHC II0/0 | 8 (4) | — | 7 (6) | — | 10 (5) |
*
Percentage of cells staining positively for the indicated antibody, with mean fluorescence intensity in parentheses.
†
Average values for isotype matched control antibodies.
‡
B-cell lymphoma.