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Journal of Virology logoLink to Journal of Virology
. 1989 Feb;63(2):677–682. doi: 10.1128/jvi.63.2.677-682.1989

Inhibition of human T-cell leukemia virus type I replication in primary human T cells that express antisense RNA.

T von Rüden 1, E Gilboa 1
PMCID: PMC247738  PMID: 2463378

Abstract

The human T-cell leukemia virus type I is associated with adult T-cell leukemia-lymphoma in humans, a disease which is induced by a malignant transformation of T lymphocytes. Retrovirus vectors carrying human T-cell leukemia virus type I-derived sequences in reversed transcriptional orientation were used to express antisense RNA transcripts in primary human leukocytes. Human T-cell leukemia virus type I replication and virus-mediated immortalization were inhibited in cells harboring antisense constructs. This study suggests that retrovirus-mediated antisense RNA inhibition can be used to protect primary human T-lymphocytes from human T-cell leukemia virus type I-mediated cell transformation.

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Selected References

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