Figure 3.

Correlation of thymus mass and absolute numbers of DCs per thymus in wild-type (▵), c-kit⁻γ_c⁺ (⧫), c-kit⁺γ_c⁻ (▴), c-kit⁻γ_c⁻ (■), and c-kit⁺γ_c⁺RAG-2⁻ (○) mutants. Postnatal-day-5 thymi from 22 mice of the indicated genotypes were individually analyzed for weight in milligrams and for the total number of DCs that were quantified by FACS as shown in Fig. 2. For c-kit and γ_c mutants, the number of DCs is roughly proportional to the thymus mass, rather than genotype. For RAG-2 mutants, the weight is reduced approximately threefold whereas the number of DCs is comparable with wild-type mice.