Figure 1.
In vivo CTLA-4 blockade slows or prevents the outgrowth of C2 tumors. C57BL/6 mice were injected with 2.5 × 106 C2 cells. Data are mean tumor areas from a single representative of three separate experiments in which groups of five mice received 100-μg intraperitoneal injections of either a control antibody or anti-CTLA-4 (CTLA-4 blockade) on days 7, 10, and 13 after tumor cell injection. The fraction of animals in each group that formed tumors is provided in parentheses next to corresponding marker designations. Note that the lower error bars for CTLA-4 blockade-treated mice have been omitted for clarity.