TABLE 6.

Expected Po-210 toxicity to humans as a function of the systemic burden in megabecquerel/kg-body-mass, based on animal data and the HF model.

Systemic burden range (MBq/kg-body-mass)	Central estimate of the risk (%) of death from deterministic effects	Expected survival time (days)	Expected histopathology	Expected hematological effects
> 1	100	1 to 28	Massive, rapidly-occurring damage to the kidney and other organs including bone marrow	Severe loss of lymphocytes, WBCa, RBCb, and hemoglobin
0.4 to 1	100	50 to 250	Rapidly occurring damage to kidney and likely other organs including bone marrow	Moderate to severe loss of lymphocytes, WBC; declines in RBC and hemoglobin at time of death
0.03 to 0.3	1 to 100	300 to 500	Slowly occurring damage to kidney and likely to other organs including bone marrow	Early WBC reduction followed by recovery; possibly delayed recovery since high-LET radiation is involved
0 to 0.02	< 1	Normal lifespan for most	Mild lesions in kidney and possibly other organs; cancers and life shortening possible	Minor effects if any

^aWBC = white blood cells.

^bRBC = red blood cells.